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Topics - ਅਮਨ ਕੌਰ 🥀

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1
Complaints / What is this illuminati ish...
« on: December 13, 2016, 07:17:30 AM »
Why is my name like thisssssssss:

2
Maan-Sanmaan/Respect+ / 109th birthday of Shaheed Bhagat Singh Ji
« on: September 28, 2016, 03:31:47 AM »
109th Birthday of Shaheed Bhagat Singh
For a 23 year old who so happily gave his life for millions, someone who had such passion regarding his country, let's not limit Bhagat Singh's soch to his gun (he only fired 3 times) let's not feel we should label him "Sikh" because there is no need to claim Bhagat Singh, let's believe what he believed in, let's try to create the India he so longed for. Let's be the change we all want to see 8->
"It is easy to kill an individual, but you cannot kill the ideas"- so this year let's stray away from bhagat singh ne vairi marreya, gorreya nu pajjayeya and let's actually read more about what he was and what he stood for because it sure as hell wasnt about shooting dushmans!

#ParnaamShaheedanNu

3
Gup Shup / THE LOON VS NOON DEBATE:
« on: September 01, 2016, 02:57:43 PM »
Okay, so this is it.
What do you call salt in Punjabi?

#TeamLoon

4
Gup Shup / Appreciation:)
« on: June 12, 2016, 08:44:32 AM »
~having too much vehla time problems~ :akh:
APPRECIATION
Yesterday is not ours to recover, but tomorrow is ours to win or lose~ Lyndon B Johnson

In the last few years, perhaps decades everything has unfortunately become a lot more about "me". Really we only care about what we need or what we want. We say we think about others but do we? In reality mainu ni lagda :smh:

Everything is taken for granted, nothing is appreciated, eh ta saareya kohl hai, ehde vich ki hai? Falane de munde/ kuri oh uni ch janda mai kyu ni, oh Mercedes lehn lagga mere kohl kyu nahi, oh yar ohne ehde wadhi kothi paa ti, appa bhi aidha karna. Why don't we see ke rabb appa nu savere uthan da mauka dehnda, ke sadhe kohl koi level di parhayi te hai, ke sanu jidha marzi hai chahe bus hi hai kithe jaa ta sakde ah sadhe hath pair te teek ne, kothi hai ya ghar sirr upar chatt te hai :worried:


By others I don't mean randomers we see once or twice a day, I mean we're quick to thank that random girl who leaves the door open so we don't have to wait in the cold, or that guy who always stands up in the bus to give you their seat, I mean apne. Our very own families. Those that deep down we know we love the most, those that nurture and support us all day, everyday, they've had our backs since #day1 :win:

Why do we feel ke we need a mothers day or a fathers day to whip out a 3 paragraph status to preach to the world how much we love our parents, why can't we simply allow the status and say "thanks mum, thanks dad I love you" the other 365 days we have? :worried:
The main point is, don't treat your parents in a way that we will regret, they're not going to be around forever, spending those hours making the :money: can wait, you're not going to go bankrupt if you don't take up every opportunity to take up overtime or putting the books away one day and spending it with the family isn't going to mean you fail your classes :S:

It's not even that we do this intentionally but duniya busy hi ehni hogi ke appa nu pata bhi nahi chalda ke adha saal lang vi janda hai te appa bas ohi dhakkeya ch fasse paye ah ke ah saal ho jawe, mainu promotion milje, ah ghar leh ho jawe, ah ik vaar graduate ho jawa
that we don't even realise ke we're already XX years old, that we don't think about how old our parents also are. Taking out a few minutes of our day isn't going to ruin our lives, just put the phone down and socho ke jinna bhi mileya hai bohat hai but agge wadhana bhi chahida but cost ki hai ohs agge wadhan da, jinna hai ohne da shukar karo and I'm sure you will not only feel happier but you'll also realise how much you already have, not what you need!

 :nothing: manz done. #AmanSpeaks

5
Sports Khelan / LEICESTER CITY PREMIER LEAGUE CHAMPIONSSSSSS!!!!
« on: May 16, 2016, 03:48:12 PM »
So, apologies if this is in the wrong section *hath jorh ke*
I know I'm late but exam season yanoe+ I hadn't quite taken this 5,000-1 thing in yet :banana:

LEICESTER CITY WIN THE PREMIER LEAGUE AND BECOME KINGS OF ENGLANDDDDD!!!!

 
This is the squad looking quite happy indeed. You can see Vardy's head :laugh:


This is the man Riyad Mahrezzzzz :love: :photo:


A little bit of banter for those saying Leicester could never make it :laugh:
(if only my grades could pull a 'leicester' now :rabb:

6
Jokes Majaak / Majh on sale
« on: April 09, 2016, 04:28:57 AM »



Lmao what :laugh:

7
Maan-Sanmaan/Respect+ / 23.03.1931
« on: March 23, 2016, 04:54:05 AM »


Ajj de din (on which holi happens to fall) Bhagat Singh, Rajguru and Sukhdev nu fansi laggayi gayi si.


8
Beauty Fashion LifeStyle / tips for the girls (...and guys maybe)
« on: December 27, 2015, 03:22:11 PM »
Some random tips I've found.
#1 Put the tip of the pencil near a flame for about 30 seconds and let it cool for 15 minutes or so. It will now give you a thick and intense line, the way any gel liner would :wow:

#2 After applying lipstick, put a tissue paper over your lips and apply powder over it. This will set the colour and give you a long lasting effect.

#3 Fill a bowl with cold water. Apply your nail colour and dip your fingers in the bowl. It speeds up the drying process.

#4  To stop hair grips sliding out your hair, simply lay a tissue paper on a table put the grips on it and spray them with any stiff hold hairspray. This will make them stay on your hair longer and stop them from sliding out every other minute.

#5 Dry shampoo is the best way to fix greasy hair when you can't wash your hair. But if for some reason, you can't find one, then use baby powder as it does exactly the same thing. Put some powder on your hairline and rub it in. It will take the greasiness away and make your hair look good.

#6 If you can't get make up wipes, simply use baby wipes- they are more readily available and do the job- being kinder to your skin too!

#7 Braid your hair on both sides really tight and go to bed. When you wake up, untangle them, spray and scrunch it and you'll be left with perfect beach waves without using a curling iron

#8 Use a credit card behind your lashes while applying mascara. It not only straightens out your lashes, but also stops the mascara from smudging on your eyelids.

SHARE YOUR IDEAS TOO GUYS AND GIRLS..
Although I assume it'd be mainly girls..

...
Oh, to make your hair look thicker asap, brush a little eyeshadow on your parting

9
MPs have overwhelmingly backed UK air strikes against so-called Islamic State in Syria, by 397 votes to 223, after an impassioned 10-hour Commons debate.
A total of 66 Labour MPs sided with the government as David Cameron secured a larger than expected Commons majority.
The PM said they had "taken the right decision to keep the country safe".
Labour leader Jeremy Corbyn had said the case for war did "not stack up" but shadow foreign secretary Hilary Benn had urged MPs to "confront this evil".

Welcoming the Commons result, Foreign Secretary Philip Hammond said Britain was "safer because of the actions taken by MPs today".
He added: "Military strikes alone won't help Syria, won't keep us safe from Daesh. But this multi-strand approach will."

The UK has been bombing IS (also known as Isis and Daesh) in Iraq since last year and the vast majority of Conservative MPs supported allowing UK air strikes in Syria as well, with just seven - far fewer than expected - voting against.
The SNP, all of whose 54 MPs opposed military action, said it was disappointed and feared the outcome would lead "to Iraq and Libya all over again".

Mr Corbyn had argued that air strikes would "almost inevitably" result in the deaths of innocent people - but his party was split, with senior Labour figures - including 11 members of the shadow cabinet - voting with the government after they were given a free vote.
The 66 Labour MPs who backed military action was equivalent to 29% of the parliamentary party.
Reacting to the vote, aides to Mr Corbyn said a majority of the parliamentary party and the shadow cabinet had backed his position and the leader's authority had been "enhanced".

Shadow international development secretary Diane Abbott said Mr Corbyn was more in line with the public than the prime minister, telling the BBC that "very soon public opinion will tire of Cameron's war".
But the United States, which along with France, Russia and other countries are already conducting missions in Syria, welcomed the vote, saying "it looks forward to having UK forces flying with the coalition over Syria".
Anti-war protesters staged a demonstration outside Parliament as MPs debated the issue, with one woman crawling under a lorry and refusing to move. She is reported to have been arrested.

Mr Cameron had opened the debate insisting Britain must decide whether it wanted to take on the "evil" of IS, which he said should be referred to as Daesh, in Syria or "wait for them to attack us".
He refused to apologise for saying opponents of military action were "terrorist sympathisers" but said there was "honour" in voting for or against military action.
He also defended his claim that there were 70,000 moderate opposition fighters in Syria, saying it was the estimate of the Joint Intelligence Committee - the UK's senior intelligence body.
But Mr Corbyn accused the PM of rushing the vote because he understood "public opposition to his ill thought-out rush to war is growing".
And he disputed Mr Cameron's claim about ground troops, saying it was "quite clear there are no such forces" and only extremists would take advantage of the strikes against IS.



FULL STORY: http://www.bbc.co.uk/news/uk-politics-34989302

ABSOLUTELY DISGUSTED :smh: :smh: :smh: :smh: :smh: :smh: :smh: :smh:

10
A BBC presenter threatened to eject a panellist live on-air after he attempted to protest about the lack of media coverage of violence against Sikhs in the Punjab.

Appearing on Sunday Morning Live, Jagmeet Singh, from the educational charity Basics of Sikhi, stood up in front of the camera and interrupted presenter Sian Williams.

Mr Singh said: “I have to say Sikhs are being killed in Punjab and nobody is reporting it. Please report it.” 

Visibly frustrated by the disruption to the show, Williams hit back: “Jagmeet I will have to get you taken out unless you allow polite and respect for guests here and our audience at home.”

After the altercation – which lasted just under a minute – Williams diverted viewers' attention to an unrelated clip. When cameras returned the panel, Mr Singh was no longer there.

Basics of Sikhi, an educational charity based in the UK which aims to spread the Guru’s wisdom, accused the presenter of belittling Mr Singh.

The charity said on Facebook: “So disappointed by the BBC’s treatment of Jagmeet Singh on Sunday Morning Live this morning. The presenter shut down Singh and repeatedly belittled him from bringing up the issue of violence against Sikhs in Punjab."

The charity also linked to a petition, boasting 70,000 supporters, urging the BBC to cover violence in the Punjab.

The petition states: “Despite the BBC having large presence in India with many reporters stationed there – it has not picked up this story. There is no mention of this on any of the their news media outlets in India or here in the UK”.

Others praised Singh for bringing the issue up. One Twitter user, Rupinder Kaur, posted: “Fair play to Jagmeet Singh – I am outraged that the BBC and others are not reporting the killing of Sikhs in Punjab.”

A BBC Spokesperson said: "On live TV unplanned things happen and this was dealt with professionally and appropriately by Sian."


Right or wrong? :wait:

11
A terminally ill man has announced the date of his death on LinkedIn, just days before his plans to travel to Switzerland in order to end his life surrounded by his family.

Simon Binner, 57, from Surrey, said he has plans to die in the Eternal Spirit in Basel on Monday following his diagnosis of Motor Neurone Disease earlier this year.

"My MND accelerated very rapidly. The sawbones initially thought I would last until 2017/2018, but they were mistaken- no worries it's an inexact science" He also went on to say that there was "nothing positive" about his disease.

MND is a neurodegenerative condition where specialist nerve cells in the brain stop working, causing a rapid loss of muscle control. There is no cure yet.

The businessman, educated at Cambridge, also said his funeral will be help next month.
Mr Binner criticised the UK law preventing assisted suicide calling it "nonsense".

Debbie Binner, 51, said her husband's condition was like "waking up to a nightmare every day".
Mr Binner's wife of 14 years said her husband had changed from a "high energy workaholic" with a "huge group of friends" to being unable to care for himself in just "seven months"

GIVE YOUR VIEWS!
-Aman:)

12
Gup Shup / Prince Narula Appreciation Topic (PNAT) BB9
« on: October 12, 2015, 11:32:44 AM »
 :happy: :happy:
Okay! This is my attempt at making a Prince Narula APPRECIATION TOPIC.
Jo bhi Prince aka The KING ♚ of Reality related gal howe, you can mention it here :happy:
JUST FOR FUN TOPIC, no seriousness.
Made by me- the Queen :mean: :laugh:
Okay I'm done :bye:

HO JAWO SHURU!!!!!!!!!!

13
Introductions / New Friends / thora delayed intro
« on: August 04, 2015, 05:08:30 AM »
Ehne well one Topix dekh ke yaad aya ke mai ni banaya si :smh:
So mai hun 8 months later banauna chaundi ah.
Hi I'm Neet or Aman. Karo swagat please Pease please :blush:

14
Knowledge / The effects of using cocaine on relapse on the brain
« on: August 02, 2015, 10:28:38 AM »
Recent findings on the effects of cocaine on the brain show that the drug causes major changes that influence the risk of relapse under stress.

A new molecular mechanism in the reward center of the brain has been discovered by Dr. Peter McCormick and colleagues at the University of East Anglia, U.K. This influences how recovering cocaine addicts might relapse after stressful events and also points to a potential basis for treatment to protect against relapses.

“Relapse among cocaine addicts is a major problem. We wanted to find out what causes it,” said McCormick.

They focused on the interaction between two neuropeptides, corticotropin-releasing factor (CRF) and orexin-A in the ventral tegmental area of the brain. These are messenger molecules- in the reward centre of the brain (also controlling addiction, motivation etc). The tests carried out were on rat brain cells and live rats and measured the effects of cocaine.

“We had speculated that there might be a direct communication between neuroreceptors controlling stress and reward,” McCormick said. “When we tested this, we found this to indeed be the case. Our research showed that the release of neuropeptides influences activity in this part of the brain and that profound changes occur at the neuroreceptor level due to exposure to cocaine.”

In The Journal of Neuroscience, the team reported that they found evidence for “pharmacologically significant interactions between CRF and orexin-A.” Cocaine binds to these neuroreceptors and “promotes long-term disruption” through which the drug “sensitizes cells to the excitatory effects of both CRF and orexin-A, thus providing a mechanism by which stress induces cocaine-seeking.

“We showed that cocaine disrupts the interaction between receptors and these changes could increase the risk of relapse under stressful conditions,” McCormick added.

“Importantly, we identify a potential mechanism for protection against such relapse. By restoring the broken interaction, we may be able to minimize stress-driven relapse in addicts. This research lays the groundwork for the development of such approaches.

“Although our study is in rodents, the same receptors have been shown to impact human stress and drug addiction. Cocaine has a relatively unique effect on the brain. However, the reward center is crucial for addictive behaviors.

“Studies on post-traumatic stress disorder have shown traumatic events can have profound influences on receptors in this region of the brain, perhaps rendering soldiers more prone to addiction. Although speculative, it would not surprise me to see similar results in other situations, whether drug- or stress-related.”

Commenting on the study, journal editor Teresa Esch, Ph.D, of Harvard Medical School,  writes that the neuropeptide orexin “is best known for its roles in arousal and feeding.”

Orexin neurons are activated by hunger and by the presence of food or food-related stimuli, she said. In addition, “cues associated with other rewards, including addictive drugs, also activate orexin neurons, leading animals to seek these rewards.”

Orexin also plays a role in stress-induced reward-seeking, Esch said. One set of neurons where this occurs is dopaminergic neurons in the ventral tegmental area. These neurons express the CRF receptor. CRF does not normally trigger dopamine release, but it can do so after exposure to cocaine.

These results suggest that exposure to cocaine disrupts the regulation of reward-seeking, Esch writes. “This may explain stress-induced relapse in former cocaine users.”

Further research should investigate which signal-triggering molecules in the brain contribute to stress-induced pursuit of rewards such as cocaine, she concludes.

A team of experts led by John R. Mantsch, Ph.D, of Marquette University has also examined this issue. In the Journal of Neuroscience, they state, “Cocaine addiction is associated with a persistent susceptibility to drug relapse that emerges in an intake-dependent manner with repeated use.”

Understanding the neurobiological mechanisms that underlie relapse in cocaine addicts “is critical to the development of effective treatment,” they believe.

Much evidence suggests that stress contributes to relapse, they report. For example, stress promotes craving in abstinent cocaine addicts, and triggers relapse in experiments on rodents. In their tests on rodents, they show that repeated cocaine use alters the way stress affects brain neurons, and that this is intake-dependent, i.e., linked to the amount of prior use of the drug.

As with the McCormick study, this work showed that risk of relapse is determined in the ventral tegmental area, and linked to heightened CRF responsiveness in this area. But “the precise mechanism of CRF regulation of dopaminergic cells in the ventral tegmental area is unclear,” they write.

Nevertheless, it appears that repeated cocaine exposure raises CRF responsiveness, and lowers any inhibitory effects, “likely resulting in a net shift toward greater CRF regulation of dopaminergic cells.”- dompamingeric being cells that are shown to react to dopamine.

“The ability of stressful life events to precipitate drug use through actions involving CRF may be a consequence of excessive cocaine use,” they write. “Identification of the precise mechanisms through which CRF activation produces cocaine-seeking should provide important insights,” they conclude.

References

McCormick, P. et al. Orexin-CRF Receptor Heteromers in the Ventral Tegmental Area as Targets for Cocaine. The Journal of Neuroscience, 29 April 2015, 35(17), 6639-53. doi: 10.1523/JNEUROSCI.4364-14.2015

Esch, T. This Week in the Journal: Orexin and CRF Receptors Form Heteromers. The Journal of Neuroscience, 29 April 2015, 35(17).

Blacktop, J. M. et al. Augmented Cocaine Seeking in Response to Stress or CRF Delivered into the Ventral Tegmental Area Following Long-Access Self-Administration Is Mediated by CRF Receptor Type 1 But Not CRF Receptor Type 2. The Journal of Neuroscience, 3 August 2011, Vol. 31, pp. 11396-403. doi: 10.1523/JNEUROSCI.1393-11.2011

Obviously this study does raise questions of generalisability from rats to humans, also ethics can also be questioned, it is fair to expose rats or any other animal to such substances which we may consider to be unhealthy and so harmful for humans.

NEUROPEPTIDE: protein like molecules that are used by neurons to convey signals to each other.
NEURON: Nerve cell which electrical impulses pass along.
I'm sorry it's long :dnk:

15
Swedish researchers at Uppsala University and the Karolinska Institute have found that genes that control the biological clocks in cells throughout the body are altered after losing a single night of sleep, in a study that is to be published in the Journal of Clinical Endocrinology and Metabolism.

“Previous research has shown that our metabolism is negatively affected by sleep loss, and sleep loss has been linked to an increased risk of obesity and type 2 diabetes. Since ablation of clock genes in animals can cause these disease states, our current results indicate that changes of our clock genes may be linked to such negative effects caused by sleep loss”, says Jonathan Cedernaes, lead author on the study and a researcher at Uppsala University.

For the study the researchers studied 15 healthy normal-weight men who on two separate occasions came to the lab for almost 2-night long stays. During the second night the participants slept as usual (over 8 hours) in one of the two sessions, while they were kept awake in the other of these sessions, but in random order. To minimize the influence of various environmental factors, light conditions, food intake and activity levels in the lab were strictly controlled and the participants were bed-restricted when they were kept awake.

Following the second night on both occasions that the men were studied, small tissue samples were taken from the superficial fat on the stomach, and from the muscle on the thigh – two kinds of tissues that are important for regulating metabolism and controlling blood sugar levels. Blood samples were also taken before and after the participants had consumed a sugar solution to test their insulin sensitivity, a practice commonly done to exclude the presence of diabetes or a metabolic state called impaired insulin sensitivity, which can precede type-2 diabetes.

Molecular analyses of the collected tissue samples showed that the regulation and activity of clock genes was altered after one night of sleep loss. The activity of genes is regulated by a mechanism called epigenetics. This involves chemical alterations to the DNA molecule such as methyl groups – a process called methylation – which regulates how the genes are switched on or off. The researchers found that clock genes had increased numbers of such DNA marks after sleep loss. They also found that the expression of the genes, which is indicative of how much of the genes’ product is made, was altered.

“As far as we know, we are the first to directly show that epigenetic changes can occur after sleep loss in humans, but also in these important tissues”, says Dr. Cedernaes. “It was interesting that the methylation of these genes could be altered so quickly, and that it could occur for these metabolically important clock genes”, he continues.

The changes that the researchers observed were however different in the adipose tissue and the skeletal muscle. “This could suggest that these important molecular clocks are no longer synchronized between these two tissues”, Dr. Cedernaes says. “As such, ‘clock desynchrony’ between tissues has been linked to metabolic pathologies, this could suggest that these tissue-specific changes were linked to the impaired glucose tolerance that our participants demonstrated after the night that they had been kept awake”

The researchers do not at this stage know how persistent these changes are. “It could be that these changes are reset after one or several nights of good sleep. On the other hand, epigenetic marks are suggested to be able to function a sort of metabolic memory, and have been found to be altered in e.g. shift workers and people suffering from type 2 diabetes”, Dr. Cedernaes points out. “This could mean that at least some types of sleep loss or extended wakefulness, as in shift work, could lead to changes in the genome of your tissues that can affect your metabolism for longer periods”, Dr. Cedernaes concludes.


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